Advant tablet

Generic of Advant tablet

Candesartan cilexetil

Manufacturer Advant tablet

Getz Pharma

Price of Advant tablet

Advant 8mg tablet (box of 14): MRP: 400.00 rs

Advant 16mg tablet (box of 14): MRP: 605.00 rs

NOTE: Advant tablet is a prescription drug.

Description:

Candesartan is a selective angiotensin 2 receptor blocker.

Clinical pharmacology:

Mechanism of action:

Candesartan blocks the angiotensin 2 receptor and promotes vasodilation and stops aldosterone secretion.

Therapeutic Indications:

· Advant tablet is used for the treatment of hypertension, either alone or in combination with other medicines (anti-hypertensives).

· It is used for adults and children (Age= 1-<7 years).

· It is used for the treatment of heart failure and impaired left ventricular systolic function (left ventricular ejection fraction < equal to 40%.

Dosage and administration:

1.   Hypertension:

Adults:

The recommended usual dose is one or two tablets per day with dose range from 8-32 mg per day.

Pediatrics:

Children less than 1 year of age must not receive advent tablet.

Children 6 - < 17 years of age:

1) For less than 50kg: dose range is 2-16mg per day

2) For less tha 50kg: 4-32 mg per day.

2.   Heart failure:

The recommended dose is 32 mg once daily. For further assistance ask your pharmacist.

3.   Special population:

Renal insufficiency:

No dose adjustment is needed.

Hepatic insufficiency :

For patient with moderate hepatic insufficiency, starting dose should be 8 mg.

Adverse reactions:

For adult hypertension

·        Headache

·        Backpain

·        Pharyhngitis

·        Dizziness

·        Fever

·        Paraesthesia

·        Vertigo

·        Dyspepsia

·        Gastroenteritis

·        Tachycardia

·        Palpitation

·        Increase level of creatinine Phosphokinase

·        Hyperglycaemia

·        Hypertriglyceridemia

·        Hyperuricaemia

·        Myalgia

·        Epistaxsis

·        Anxiety

·        Depression

·        Rash

·        Increase in sweating

·        Hematuria

·        Angina pectoris

·        Myocardial infarction

·        Angioderma

Pediatrics hypertension

Renal diseases

Heart failure (adults)

·        Small increase in Serum creatinine and serum potassium levels

·        Small decrease in Hb and hematocrit.

Contra-indications

·       Hypersensitivity to the drug or its excipients

·       Pregnant women in 2nd or 3rd trimester cannot take this medicine.

·       Patient having cholestasis or severe hepatic impairment.

·       Children < 1 year of age.

·       Patient having diabetes militus or renal impairment.

Precautions

·        Warning-fetal toxicity

·        Hypotension

·        Renal aetery stenosis

·        Haemodialysis

·        Aortic and mitral valve stenosis

·        Anesthesia and surgery.

·        Impaired renal function

·        Hyperkalemia

·        Hyperaldosternoism

·        Nursing mothers

Drug Interactions

·        Other anti-hypertensive drugs

·        Potassium sparing diuretics, potassium supplements, salt substitutes containing potassium.

·        Drugs that increase potassium levels e.g. Heparin.

·        ARBs

·        NSAIDs

·        ACE inhibitors

·        ACE inhibitors combined with mineralocorticoid receptor antagonist.

·        Aliskiren

Over dosage :

·        Due to over dose, hypotension may occur.

·        Administer isotonic saline solution, or sympathomimetic medicinal products.

Storage:

·        Do not store above 30 degree celsius.

·        Protect from sunlight and moisture.

·        The expiry date refers to the product correctly stored at required conditions.

·        Keep out of reach of children.

·        To be sold on prescription of a registered medical practitioner only.