famopsin tablet uses

فیموپسن گولی کس طرح استعمال کریں

Written by Dr Naima Zafar, [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan)

Brand name:

Famopsin 20, Famopsin 40

Generic name:

Famotidine

Available dosage forms and their doses:

Tablet

Pack size and Price:

1 strip has 10 tabs.

Famospin 20: 235.60 Rs. (1 box = 2 strips)

Famospin 40 : 235.60 Rs. (1 box = 1 strip)

Therapeutic class

Ant-acid

Pharmacological class

Histamine H2-receptor antagonists or H2-blockers

Manufacturer

HIGH-Q

Storage

• Store at room temperature.

• Protect from light and moisture.

• Please keep it away from children.

  
  

Prescription drug:

Available with or without a doctor's prescription

Clinical pharmacology (mechanism of action)

"Competitive inhibition of histamine at H2 receptors on gastric parietal cells leads to suppression of gastric acid secretion."

Indications and doses

Treatment of benign gastric and duodenal ulceration

Adult: 40 mg once daily for 4-8 weeks, dose to be taken at night.

Maintenance treatment of duodenal ulceration

Adult: 20 mg once daily, dose to be taken at night.

Reflux oesophagitis

Adult: 20-40 mg twice daily for 6-12 weeks; maintenance: 20 mg twice daily.

Zollinger-Ellison Syndrome

Adult oral: Initial dose 20 mg orally every 6 hours

Maximum dose: 160 mg orally every 6 hours

Side effects

Common:

• Constipation

• diarrhea

• dizziness

• fatigue

• headache

• myalgia

• skin reactions

Uncommon:

• Decreased appetite

• dry mouth

• pruritus

• altered taste

• vomiting

Rare:

• Anxiety

• chest tightness

• insomnia

• decreased libido

• neutropenia

• seizures

• severe cutaneous reactions (SCARs)

Interactions

• Ketoconazole

• itraconazole

• atazanavir

• warfarin

• sparsentan

• dasatinib

• pazopanib

  
  

Contraindications

Hypersensitivity to famotidine or other H2 antagonists

Pregnancy

Should be avoided unless the potential benefit outweighs the risk

Lactation

Present in milk. It is advised to avoid

Elder Patients:

In elder patients, slower kidney function can make drugs stay in the body longer, raising the risk of side effects. Doctors may lower the dose or adjust the schedule to prevent this.

Renal Impairment

Seizures occur in rare cases.

Dose adjustment in renal impairment: Use normal dose every 36-48 hours or use half normal dose if eGFR is less than 50 mL/min/1.73 m²

Precautions

In case of gastric cancer, H2 receptor antagonists might mask symptoms in adults

Counselling points:

• It’s usually taken once or twice daily, 15–60 minutes before meals or drinks that could cause heartburn

• If taking once daily, it's best to take it before dinner or bedtime, as night time reflux is common in up to 79% of people with GERD

  
  

• If you miss a dose, take it when you remember unless it's almost time for the next one. In that case, skip the missed dose. Don’t double up.

annuva tablet uses

Written by Dr Taha Murtaza [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan)

Generic:

Diclofenac free acid

Composition:

Active pharmaceutical ingredient:

Each dispersible tablet contains 46.50mg diclofenac diclofenac-free acid (Novartis specs) equivalent to 50mg of diclofenac sodium.

Excipients:

• Cellulose

• Micro-crystalline

• Sodium starch glycolate

• colloidal anhydrous

• castor oil

• hydrogenated talc

Pack size:

Each box contains 20 dispersible tablets

Manufacturer:

Novartis Pharma (Pakistan) Ltd.

Therapeutic class:

NSAIDs

Pharmacological class:

Prostaglandin biosynthesis inhibitor

Indications:

• Pain and inflammation after surgery e.g. dental or orthopedic.

• Painful inflammation after trauma

• Flareups of joints and bones pain and inflammation

• Acute pain due to gout

• non-articular pain

• Pain in vertebral column disorders

• Dysmenorrhoea or adnexitis

• Painful inflammatory infections of ENT.

Dosage and recommendation:

• 2-3 tablets, 2-3 times daily

• For dysmenorrhoea, 1-2 tablets 2-3 times per day.

• Maximum dose: 4 tabs per day 2-3 times

Special population:

Renal impairment:

Contra-indicated

Hepatic impairment:

Contra-indicated

Children:

• <14 years; not recommended

• 14 or > 14 years; 2 tablets in divided doses should not exceed 150 mg

Elderly patients:

• 65 or >65 years; no adjustment is needed

• caution is needed for weak elderly patients or patients with low body weight.

Cardiovascular disease:

• Generally not recommended

• A dose of less than equal to 100mg can be taken if treatment is needed for more than 4 weeks.

Method of administration:

• Taken before meal

• Drop a tablet in a glass of water, stir well, and then drink it. If the remaining amount of the drug is left in the glass, it should be rinsed again with a small amount of water and drank again.

Contra-indications:

• hypersensitivity to the drug or any of its constituents.

• Gastric or intestinal ulcer

• Last trimester of pregnancy

• Hepatic impairment

• Renal failure (GFR<15ml/min/1.73m2)

• Severe cardiac failure

• NSAIDs

Side-effects (Common)

• headache

• dizziness

• vertigo

• nausea/vomiting

• diarrhoea

• dyspepsia

• abdominal pain

• flatulence

• decreased appetite

• Transaminases decreased

• Rash

Interactions:

Diclofenac sodium shows interactions with the following drugs:

• CYP2C9 inhibitors

• lithium

• digoxin

• diuretics and anti-hypertensives

• ciclosporin and tacrolimus

• drugs known to cause hyperkalemia

• Quinolone antibacterials

• Other NSAIDs and corticosteroids

• anti-coagulants and anti-platelet agents

• SSRIs

• Anti-diabetics

• phenytoin

• methotrexate

• CYP2C9 inducers

Pregnancy:

Not recommended

Lactation:

Not recommended

Fertile women:

Not recommended for women who are going to conceive

Clinical pharmacology:

"Diclofenac sodium inhibits prostaglandin biosynthesis."

Warnings and precautions:

• Risk of serious cardiovascular and G.I. events

  
  

• G.I. bleeding, ulceration, and perforation

Storage:

• Store below 25 degrees Celsius

• Protect from light and moisture

• All drugs should be kept out of reach of children.

  
  

Jinnat (Ghosts) came to a shop at night in Burns Road Saddar Karachi

Written by Dr. Taha Murtaza

This is the story of a general item shop located in an old city area usually called 'Burns Road', a famous food street in Karachi, Pakistan, a person called 'Bhai Chhotu' claims that ghosts (Jinnat) came to his shop at night.

In an interview taken by a reporter on a news channel, Bhai Chhotu says that he opens his shop at night and closes at day time. He opens his shop just because he knows that unseen creatures will come to his shop and buy some stuff for their family. He also claimed that they gave him a greater amount than the bill.

He also added a short story that one night a person came to his shop and gave him an excess amount and left the shop when he came out to give the money back, the person disappeared, he searched in all directions but no one was there.

He also added that his shop had completed a half-century, and his father also witnesses ghosts (Jinnat) and tells him their stories. He said that when these types of creatures came to his shop, he recognized them easily by feeling them. According to him, these kinds of people have never seen him again. He never gets afraid while communicating with them, just because he has been meeting with them for a long time.

Reference:

Express News Channel