famopsin tablet uses

فیموپسن گولی کس طرح استعمال کریں

Written by Dr Naima Zafar, [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan)

Brand name:

Famopsin 20, Famopsin 40

Generic name:

Famotidine

Available dosage forms and their doses:

Tablet

Pack size and Price:

1 strip has 10 tabs.

Famospin 20: 235.60 Rs. (1 box = 2 strips)

Famospin 40 : 235.60 Rs. (1 box = 1 strip)

Therapeutic class

Ant-acid

Pharmacological class

Histamine H2-receptor antagonists or H2-blockers

Manufacturer

HIGH-Q

Storage

• Store at room temperature.

• Protect from light and moisture.

• Please keep it away from children.

  
  

Prescription drug:

Available with or without a doctor's prescription

Clinical pharmacology (mechanism of action)

"Competitive inhibition of histamine at H2 receptors on gastric parietal cells leads to suppression of gastric acid secretion."

Indications and doses

Treatment of benign gastric and duodenal ulceration

Adult: 40 mg once daily for 4-8 weeks, dose to be taken at night.

Maintenance treatment of duodenal ulceration

Adult: 20 mg once daily, dose to be taken at night.

Reflux oesophagitis

Adult: 20-40 mg twice daily for 6-12 weeks; maintenance: 20 mg twice daily.

Zollinger-Ellison Syndrome

Adult oral: Initial dose 20 mg orally every 6 hours

Maximum dose: 160 mg orally every 6 hours

Side effects

Common:

• Constipation

• diarrhea

• dizziness

• fatigue

• headache

• myalgia

• skin reactions

Uncommon:

• Decreased appetite

• dry mouth

• pruritus

• altered taste

• vomiting

Rare:

• Anxiety

• chest tightness

• insomnia

• decreased libido

• neutropenia

• seizures

• severe cutaneous reactions (SCARs)

Interactions

• Ketoconazole

• itraconazole

• atazanavir

• warfarin

• sparsentan

• dasatinib

• pazopanib

  
  

Contraindications

Hypersensitivity to famotidine or other H2 antagonists

Pregnancy

Should be avoided unless the potential benefit outweighs the risk

Lactation

Present in milk. It is advised to avoid

Elder Patients:

In elder patients, slower kidney function can make drugs stay in the body longer, raising the risk of side effects. Doctors may lower the dose or adjust the schedule to prevent this.

Renal Impairment

Seizures occur in rare cases.

Dose adjustment in renal impairment: Use normal dose every 36-48 hours or use half normal dose if eGFR is less than 50 mL/min/1.73 m²

Precautions

In case of gastric cancer, H2 receptor antagonists might mask symptoms in adults

Counselling points:

• It’s usually taken once or twice daily, 15–60 minutes before meals or drinks that could cause heartburn

• If taking once daily, it's best to take it before dinner or bedtime, as night time reflux is common in up to 79% of people with GERD

  
  

• If you miss a dose, take it when you remember unless it's almost time for the next one. In that case, skip the missed dose. Don’t double up.