rovista tablet uses

رووسٹا گولی کا استعمال

Written by Dr. Noor Fatima [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan.

Generic:

Rosuvastatin

Dosage forms:

Tablet forms are available in different strengths: 5mg, 10mg, 20mg, and

40mg.

Therapeutic class:

Lipid-lowering agent, Statins

Pharmacological class:

HMG-CoA Reductase Inhibitors

Price:

For 10mg tab (1 strip= 10 tablets)= RS 415

For 20mg tab (1 strip= 10 tablets)= RS 640

Mechanism of Action:

HMG-CoA reductase mediates the first committed step in sterol biosynthesis. The active forms of the reductase inhibitors are structural analogs of the HMG-CoA intermediate that is formed by HMG-CoA reductase in the synthesis of mevalonate. These agents block this action.

Manufacturer:

Getz Pharma

Storage:

25-30 degrees Celsius

Prescription Drug:

Rosuvastatin should be prescribed by the physician.

Indications and Doses:

Hypercholesterolemia: It is used as an adjunctive therapy in adults with hypertriglyceridemia, hyperlipidemia, and mixed dyslipidemia.

Dose: 10-20mg PO every day, not exceeding 40mg/ day.

Slowing the progression of Atherosclerosis: It is used as an adjunctive therapy in adult patients as a part of a treatment strategy to lower total cholesterol and LDL cholesterol to target levels.

Renal Dose Adjustment:

Mild or moderate (CrCl ≥30 mL/min/1.73m²): No dosage adjustment

necessary

Side Effects:

Prevention Of Cardiovascular Events in patients at high risk of a first cardiovascular event and with risk factors for myopathy or

rhabdomyolysis.

Avoid rosuvastatin creatinine clearance less than 30mL/minute.

Contraindications:

● Hypersensitivity to drug or excipients

● Acute liver failure or decompensated cirrhosis (including

unexplained persistent elevations of LFTs)

● Gemfibrozil may increase the toxicity of rosuvastatin.

Pregnancy:

Discontinue therapy when pregnancy is recognized; alternatively, consider ongoing therapeutic needs of individual patient.

Lactation:

No data available.

folic acid tablet uses

فولک ایسڈ کی گولی کا استعمال

Written by Dr. Qaisara Tehzeeb [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan.

BRAND NAME:

· FOLIC ACID

GENERIC NAME:

· Folic acid (Folate or Vitamin B9)

AVAILABLE DOSAGE FORM:

· Folic Acid tablet BP 5mg

PRICE:

· 92 rupees per bottle, which contains 100 tablets of folic acid.

THERAPEUTIC CLASS:

· Member of water-soluble Vitamin B Complex.

· Prenatal Vitamin.

PHARMACOLOGICAL CLASS:

· Essential cofactor and precursor for enzymes required for nucleoprotein synthesis and maintenance of erythropoiesis.

MANUFACTURER:

· ZAFA Pharmaceutical Laboratories (Pvt.) Limited.

PRESCRIPTION DRUG?

· YES

MECHANISM OF ACTION:

· Folate acts as a precursor in the synthesis of Tetrahydrofolate (active form of folate), a cofactor which helps to perform various biochemical reactions such as DNA and RNA synthesis and the production of red blood cells.

INDICATIONS:

· Prevent and treat folic acid deficiency.

· Megaloblastic Anemia

· Macrocytic Anemia

· Prevent complications and birth defects during pregnancy, such as Spina Bifida

and Anencephaly.

DOSE:

· For adults and children over 1 year ( 5mg tablet once a day)

· For children less than 1 year of age (500 mcg per kg of body weight daily)

SIDE EFFECTS:

· Nausea

· Bloating

· Loss of Appetite

· Rash

· Sleep Problems

CONTRAINDICATIONS:

· Folic acid is generally safe, but in rare cases, it can cause an allergic reaction in some people.

· Pernicious anemia and aplastic anemia

· Cancer (unless you have folate deficiency)

DRUG INTERACTIONS:

· Anticonvulsants (Phenytoin, fosphenytoin and Primidone)

· Barbiturates

· Methotrexate (folate antagonist)

· Pyrimethamine

· Do not take your folic acid within 2 hours before or after taking antacids containing Aluminium and Magnesium, as they may stop folic acid from being properly absorbed.

PREGNANCY:

· Used by pregnant women as a dietary supplement to prevent neural tube defects.

 LACTATION:

· Recommended for breastfeeding women.

STORAGE:

· Store at room temperature away from light, heat and moisture.

INSTRUCTIONS:

· Folic acid can be beneficial for both kidney and liver health.

· Folic acid should never be used to treat anemia without a full investigation of the cause.

COUNSELLING:

· Keep out of the reach of children.

· Swallow the whole tablet with a glass of water.

· You can take folic acid before or after the meal.

CaC 1000 plus tablet

CaC 1000 پلس ٹیبلیٹ

Written by Dr. Khubaib [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan.

✅ Brand Name

· CaC-1000 PLUS

✅ Generic Name

· Calcium (as Calcium Lactate Gluconate + Calcium Carbonate)

· Vitamin D3 (Cholecalciferol)

· Vitamin C (Ascorbic Acid)

· Vitamin B6 (Pyridoxine Hydrochloride)

✅ Available Dosage Forms and Doses

· Effervescent tablet (dissolvable in water)

·  Each tablet contains:

· Calcium (total) ≈ 1000 mg

· Vitamin D3 ≈ 400 IU

· Vitamin C ≈ 500 mg

· Vitamin B6 ≈ 10 mg

· Flavour: Orange

· How to use: Dissolve 1 tablet in a glass of water and drink.

✅ Price

· Approx. PKR 150 to 180 per tube of 10 tablets (may vary based on pharmacy/location)

✅ Therapeutic Class

· Mineral and Vitamin Supplement

· Bone and joint health

✅ Pharmacological Class

· Calcium supplement with vitamins

· Multivitamin-mineral combination

✅ Manufacturer

· GlaxoSmithKline (GSK) Consumer Healthcare Pakistan Ltd.

·  Pataro Road, Jamshoro

✅ Storage

· Keep below 30°C

· Store in a dry place

· Protect from moisture and direct sunlight

· Keep out of reach of children

✅ Prescription Drug?

· No – Available over the counter (OTC) in Pakistan

✅ Clinical Pharmacology (Mechanism of Action)

· Calcium is essential for bone formation, muscle function, and nerve transmission.

· Vitamin D3 increases calcium absorption from the intestine and regulates bone mineralization.

· Vitamin C helps in collagen formation and enhances calcium absorption.

· Vitamin B6 supports metabolism and helps reduce fatigue and weakness.

· Together, they help build and maintain strong bones, prevent deficiencies, and support overall metabolic function.

✅ Indications and Dosages

· Indications:

· Prevention and treatment of calcium and vitamin D deficiency

· Bone health in osteoporosis or osteopenia

· During pregnancy, lactation, or menopause

· Muscle cramps or weakness due to low calcium

· Healing of bone fractures

· Supporting general immune function

· Dosage:

· Adults: 1 tablet daily dissolved in a full glass of water, after a meal

· Can be increased to 1 tablet twice daily if prescribed by a doctor

✅ Side Effects

· Usually well tolerated. Possible mild effects:

· Nausea or bloating

· Stomach discomfort

· Gas

· Mild constipation

· Rare: high calcium levels (with excessive use)

✅ Drug Interactions

· Avoid using with:

· Iron, zinc, or magnesium supplements (space them out by 2 hours)

· Certain antibiotics (like tetracyclines, fluoroquinolones)

· Thyroid medications (e.g., levothyroxine)

· Diuretics (e.g., thiazides) – may increase calcium levels

· Antacids – check for overlapping ingredients

✅ Pregnancy

· Safe to use in pregnancy when taken in recommended doses.

·  Supports the increased calcium demand during pregnancy.

✅ Lactation

· Also safe during breastfeeding – calcium and vitamins are vital for both mother and baby.

✅ Precautions

· Use with caution if you have:

· Kidney stones

· Kidney disease

· High blood calcium levels (hypercalcemia)

· Sarcoidosis or other calcium-related disorders

· Avoid exceeding the daily recommended dosage unless advised.

✅ Counselling Points (Patient Advice)

· Always dissolve tablet fully in water before drinking

· Take after meals to reduce stomach upset

· Stay well hydrated throughout the day

· Don’t take it with milk or iron supplements – separate by 2 hours

Report if you notice nausea, weakness, confusion, or irregular heartbeat (possible signs of high calcium).