rovista tablet uses

رووسٹا گولی کا استعمال

Written by Dr. Noor Fatima [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan.

Generic:

Rosuvastatin

Dosage forms:

Tablet forms are available in different strengths: 5mg, 10mg, 20mg, and

40mg.

Therapeutic class:

Lipid-lowering agent, Statins

Pharmacological class:

HMG-CoA Reductase Inhibitors

Price:

For 10mg tab (1 strip= 10 tablets)= RS 415

For 20mg tab (1 strip= 10 tablets)= RS 640

Mechanism of Action:

HMG-CoA reductase mediates the first committed step in sterol biosynthesis. The active forms of the reductase inhibitors are structural analogs of the HMG-CoA intermediate that is formed by HMG-CoA reductase in the synthesis of mevalonate. These agents block this action.

Manufacturer:

Getz Pharma

Storage:

25-30 degrees Celsius

Prescription Drug:

Rosuvastatin should be prescribed by the physician.

Indications and Doses:

Hypercholesterolemia: It is used as an adjunctive therapy in adults with hypertriglyceridemia, hyperlipidemia, and mixed dyslipidemia.

Dose: 10-20mg PO every day, not exceeding 40mg/ day.

Slowing the progression of Atherosclerosis: It is used as an adjunctive therapy in adult patients as a part of a treatment strategy to lower total cholesterol and LDL cholesterol to target levels.

Renal Dose Adjustment:

Mild or moderate (CrCl ≥30 mL/min/1.73m²): No dosage adjustment

necessary

Side Effects:

Prevention Of Cardiovascular Events in patients at high risk of a first cardiovascular event and with risk factors for myopathy or

rhabdomyolysis.

Avoid rosuvastatin creatinine clearance less than 30mL/minute.

Contraindications:

● Hypersensitivity to drug or excipients

● Acute liver failure or decompensated cirrhosis (including

unexplained persistent elevations of LFTs)

● Gemfibrozil may increase the toxicity of rosuvastatin.

Pregnancy:

Discontinue therapy when pregnancy is recognized; alternatively, consider ongoing therapeutic needs of individual patient.

Lactation:

No data available.