acefyl syrup

Dr. Misbah Khan
Apr 27
2 min read

Updated: May 9

ایسفیل سیرپ

Written by Dr. Misbah Khan [PharmD, DOW University Of Health Sciences (DUHS)], Karachi, Pakistan.

Brand:

Acefyl

Generic:

Acefylline Piperazine, Diphenhydramine

Dosage form:

Syrup

Doses:

For cough and respiratory issues:

Adults: 10-20 mL three times daily
Children (2-6 years): 5 mL three times daily
Children (6-12 years): 10 mL three times daily

For chronic obstructive pulmonary disease (COPD):

Adults: 10-20 mL three times daily
Children (6-12 years): 10 mL three times daily

For allergic conditions:

Adults: 10-20 mL three times daily
Children (2-6 years): 5 mL three times daily
Children (6-12 years): 10 mL three times daily

Price:

Rs156.75 (0.56$)

Therapeutic class:

Antihistamine

Pharmacology class:

Xanthine derivatives

Manufacturer:

Nabi Qasim Pharmaceuticals (Pvt) Ltd.

Storage:

Store it at a temperature between 15°C and 30°C in a cool, dry place,

away from direct sunlight and moisture.

Prescription drug:

Yes, it requires a prescription

Mechanism of action:

"It inhibits the PDE-4 enzyme, increasing cyclic adenosine monophosphate (cAMP) levels in cells, which reduces inflammation and improves respiratory symptoms."

Indications:

This medication is used to treat:

Bronchial asthma
Chronic bronchitis
Obstructive airway diseases
Bronchoconstriction
Allergy symptoms
Sneezing
Runny nose
Itching

Side effects:

Nausea
Drowsiness
Stomach discomfort
Diarrhea
Allergic reactions

Interactions:

Other xanthines (e.g., caffeine) (increased risk of side effects)
Corticosteroids (increased risk of adverse effects)
Beta-adrenergic agonists (increased risk of cardiovascular effects)
Lithium (potential for increased lithium levels)
CYP450 inducers (e.g., rifampin) (may reduce efficacy)
CYP450 inhibitors (e.g., erythromycin) (may increase risk of toxicity)
Alcohol (enhanced sedation and impairment)
Benzodiazepines (increased sedation)
MAO inhibitors (risk of severe hypertension)
Anticholinergic drugs (increased anticholinergic effects)
Opioids (enhanced sedation and respiratory depression)
Tricyclic antidepressants (increased anticholinergic effects and sedation)
Other CNS depressants (enhanced drowsiness and impaired cognitive

function)

Pregnancy:

According to the FDA (Food and Drug Administration), no evidence suggests Acefyl syrup poses a risk to pregnant women or their unborn babies. It can also help alleviate symptoms of cough and cold, which are common during pregnancy.

Lactation:

Breastfeeding women should consult their healthcare provider before using this syrup to ensure its safety.

Precautions:

This syrup may cause drowsiness; users should avoid activities requiring full mental alertness, such as driving or operating machinery until they understand how the syrup affects them.